Drug-resistant Plasmodium falciparum infection in immigrants and non-immune travellers

Prolonged Plasmodium falciparum Infection in Immigrants, Paris

Few immigrant travelers have Plasmodium falciparum infections >2 months after leaving malaria-endemic areas. We conducted a case-control study to identify factors associated with prolonged P. falciparum infection in immigrant travelers. Results suggest that P. falciparum infection should be systematically suspected, even months after travel, especially in pregnant women and first-arrival immigr...

Plasmodium falciparum outwits Malarone, protector of travellers.

In vitro selection of Plasmodium falciparum drug-resistant parasite lines

The in vitro selection of antimicrobial resistance in important pathogens can provide critical information on the genetic basis of drug resistance, and such information can be used to predict, anticipate and even contain the spread of resistance in clinical practice. For instance, the discovery of the role of pfmdr1 in mefloquine resistance in malaria parasites resulted from in vitro studies. H...

Maternal and neonatal immune responses to Plasmodium falciparum infection

Plasmodium falciparum infection during pregnancy has severe consequences for both mother and fetus and can lead to the trans-placental passage of malarial antigens that are capable of inducing neonatal immune responses. Between July 2003-December 2004, 228 women from Omdurman Maternity Hospital, Sudan were followed monthly during antenatal period till delivery time. We examined neonatal and mat...

Chloroquine-Resistant Plasmodium falciparum: Effect

Glucose stimulates the high-affinity processes of chloroquine and amodiaquin accumulation in owl monkey erythrocytes infected with a chloroquine-susceptible strain of Plasmodium falciparum. Although these erythrocytes have greater ability to accumulate amodiaquin than chloroquine, glucose has relatively less effect on amodiaquin accumulation than on chloroquine accumulation. In contrast to thes...